Author(s)
E.
Calamai, S.
Dall'Angelo, D.
Koss, J.
Domarkas, T. J.
McCarthy, M.
Mingarelli, G.
Riedel, L. F.
Schweiger, A.
Welch, B.
Platt, M.
Zanda
ISBN
1364-548X (Electronic)1359-7345 (Linking)
Publication year
2013
Periodical
Chem Commun (Camb)
Periodical Number
8
Volume
49
Pages
792-4
Author Address
Kosterlitz Centre for Therapeutics, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Scotland, UK.
Three fluoro-barbiturates were synthesised, showing in vivo sedative efficacy. One of them, [(18)F], was synthesised in radiofluorinated form. PET/CT Imaging with [(18)F] identified beta-amyloid over-expressing transgenic mice (betaA mice) compared to wild type and tau lines. The fluorescent barbiturate 9 was able to label betaA plaques in brain sections of betaA mice, and co-localise with a fluorescent Zn(II) indicator.