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Interests:
I am involved a range of investigations into the theme of central nervous system injury: its causes, repair mechanisms and outcome; how they might be visualized and measured objectively by neuroimaging at each stage particularly in relation to their response to therapy. These insults to the brain and spinal cord range through trauma, stroke, demyelination and epilepsy to the growth of neoplasms. I am using investigations such as MRI, MRS fMRI, diffusion and perfusion in addition to radionucleotide SPECT scanning and PET. I am interested in the ethics of research imaging and the safety aspects of magnetic resonance and ionising radiation.
Research Themes:
Clinical Neuroradiology, Magnetic Resonance developments
Key Publications:
GOUNTOUNA, E., MCINTOSH, A., MOORHEAD, W., JOB, D., LYMER, K., WHALLEY, H., WAITER, G., BRENNAN, D., MCGONNIGLE, D., AHEARN, T., CAVANAGH, J., CONDON, B., HADLEY, D., MARSHALL, I., , MURRAY, A., STEELE, D., WARDLAW, J., LAWRIE, S. Functional Magnetic Resonance Imaging (fMRI) reproducibility and variance components across visits and scanning sites with a finger tapping task. Neuroimage 2010 49, 552-560.
MARSHALL, V.L., MARSHALL, C., MARQUARDT, M., BUCKLEY, C., PATTERSON, J., HADLEY, D.M., OERTEL, W.H., BENAMER, H., KEMP, P., BURN, D., TOLOSA, E., KULISEVSKY, J., VANDER, B.T., CUNHA, L., COSTA, D., BOOIJ, J., TATACH, K., FONTES, F., CHAUDHURI, K.R., ULM, G., POGARELL, O., HOFFKEN, H., GERSTNER, A., REININGER, C., GROSSET, D.G. Parkinson’s disease is overdiagnosed clinically at baseline: a 3-year European Study with repeat [123I] FP-CIT SPECT. Movement Disorders 2009 24,500-5008 (doi: 10.1002/mds.22108).
SMITH, F.W., MUCKLI, L., BRENNAN, D., PERNET, C., SMITH, M.L., BELIN, P., GOSSELIN, F., HADLEY, D.M., CAVANAGH, J.,SCHYNS, P. Classification images reveal the information sensitivity of brain voxels in fMRI. NeuroImage 2008 40, 1643-1654. (doi:10.1016/j.neuroimage.2008.01.029)