Organisation:
Department:
Keywords:
Interests:
Computational cardiovascular mechanics
The aim of my research is to generate new scientific knowledge and methods using innovative ideas in numerical methods and biomechanics that contribute towards improved cardiovascular healthcare.
Research Themes:
Our work can be divided into four categories: cardiovascular modeling, cell mechanics, image-based mechanics, and advanced numerics.
Key Publications:
Mei, Y., Hurtado, D. E., Pant, S. and Aggarwal, A. (2018) On improving the numerical convergence of highly nonlinear elasticity problems. Computer Methods in Applied Mechanics and Engineering, 337, pp. 110-127. (doi: 10.1016/j.cma.2018.03.033)
Aggarwal, A. (2018) Determination of prestress and elastic properties of virus capsids. Physical Review E, 97, 032414. (doi: 10.1103/PhysRevE.97.032414) (PMID:29776150)
Aggarwal, A. (2017) An improved parameter estimation and comparison for soft tissue constitutive models containing an exponential function. Biomechanics and Modeling in Mechanobiology, 16(4), pp. 1309-1327. (doi: 10.1007/s10237-017-0889-3) (PMID:28251368) (PMCID:PMC5511618)
Aggarwal, A. and Sacks, M. S. (2016) An inverse modeling approach for semilunar heart valve leaflet mechanics: exploitation of tissue structure. Biomechanics and Modeling in Mechanobiology, 15(4), pp. 909-932. (doi: 10.1007/s10237-015-0732-7) (PMID:26449480)
Aggarwal, A. , May, E. R., Brooks, C. L. and Klug, W. S. (2016) Nonuniform elastic properties of macromolecules and effect of prestrain on their continuum nature. Physical Review E, 93, 012417. (doi: 10.1103/physreve.93.012417) (PMID:2687111)
Aggarwal, A. , Pouch, A. M., Lai, E., Lesicko, J., Yushkevich, P. A., Gorman III, J. H., Gorman, R. C. and Sacks, M. S. (2016) In-vivo heterogeneous functional and residual strains in human aortic valve leaflets. Journal of Biomechanics, 49(12), pp. 2481-2490. (doi: 10.1016/j.jbiomech.2016.04.038) (PMID:27207385) (PMCID:PMC5028253)
Perotti, L. E., Aggarwal, A. , Rudnick, J., Bruinsma, R. and Klug, W. S. (2015) Elasticity theory of the maturation of viral capsids. Journal of the Mechanics and Physics of Solids, 77, pp. 86-108. (doi: 10.1016/j.jmps.2015.01.006)
Aggarwal, A. , Ferrari, G., Joyce, E., Daniels, M. J., Sainger, R., Gorman, J. H., Gorman, R. and Sacks, M. S. (2014) Architectural trends in the human normal and bicuspid aortic valve leaflet and its relevance to valve disease. Annals of Biomedical Engineering, 42(5), pp. 986-998. (doi: 10.1007/s10439-014-0973-0) (PMID:24488233) (PMCID:PMC4364391)
Aggarwal, A. , Chen, J.-S. and Klug, W.S. (2014) A meshfree method for mechanics and conformational change of proteins and their assemblies. CMES – Computer Modeling in Engineering and Sciences, 98(18), pp. 69-99.
Aggarwal, A. , Rudnick, J., Bruinsma, R.F. and Klug, W.S. (2012) Elasticity theory of macromolecular aggregates. Physical Review Letters, 109, 148102. (doi: 10.1103/PhysRevLett.109.148102) (PMID:23083291)