Organisation:
Department:
Keywords:
Interests:
Tumour Angiogenesis, Radiotracer Development, In vitro testing, Method Development
Key Publications:
Andriu, A., Crockett, J., Dall’Angelo, S., Piras, M., Zanda, M. & Fleming, IN. (2018). ‘Binding of αvβ3 Integrin-Specific Radiotracers Is Modulated by Both Integrin Expression Level and Activation Status’. Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging, vol 20, no. 1, pp. 27-36. DOI
Fleming, IN., Andriu, A. & Smith, TAD. (2014). ‘Early changes in [18F] FDG incorporation by breast cancer cells treated with trastuzumab in normoxic conditions: Role of the Akt-pathway, glucose transport and HIF-1α’. Breast Cancer Research and Treatment, vol 144, no. 4, pp. 241-248.
Piras, M., Andriu, A., Testa, A., Wienecke, P., Fleming, IN. & Zanda, M. (2017). ‘Design and synthesis of an RGD peptidomimetic-paclitaxel conjugate targeting αvβ3 integrin for tumour-directed drug delivery’. Synlett, vol 28, no. 20, pp. 2769-2776. DOI
Piras, M., Testa, A., Fleming, IN., Dall’Angelo, S., Andriu, A., Menta, S., Mori, M., Brown, GD., Forster, D., Williams, KJ. & Zanda, M. (2017). ‘High Affinity “Click” RGD Peptidomimetics as Radiolabeled Probes for Imaging αvβ3 Integrin’. ChemMedChem, vol 12, no. 14, pp. 1142-1151. DOI