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Interests:
Neuroinflammation is a common factor in a variety of neurological disorders, including dementia. Thanks to molecular imaging techniques, such as positron emission tomography (PET), the extent of neuroinflammation can be detected in vivo, assisting with diagnosis and monitoring of the disease, as well as benefiting the preclinical research. During my PhD project, I will be studying 18kDa translocator protein (TSPO) as a biomarker for neuroinflammation and validating the use of novel TSPO radiotracers to image dementia-associated neuroinflammation in preclinical dementia models. In addition, I will assess the cellular distribution of TSPO in the brain under physiological and pathophysiological conditions.
Key Publications:
MacAskill et al. (2020). Quantification of macrophage-driven inflammation during myocardial infarction with 18F-LW223, a novel TSPO radiotracer with binding independent of the rs6971 human polymorphism, Journal of Nuclear Medicine.
Stadulyte et al. (2019). Analysis of PK11195 concentrations in rodent whole blood and tissue samples by rapid and reproducible chromatographic method to support target-occupancy PET studies, Journal of Chromatography B.