…addition to self-paced breathing, three different computer-paced breathing rates were imposed during the periods between end-expiration breath-hold blocks. The resulting BOLD signal timecourses and statistical activation maps were compared in…

…is accurate enough to replace DSA. Two non-invasive techniques in combination, and adding a third if the first two disagree, appears more accurate, but may still result in diagnostic errors….

IMPORTANCE: Whether conservative management is superior to interventional treatment for unruptured brain arteriovenous malformations (bAVMs) is uncertain because of the shortage of long-term comparative data. OBJECTIVE: To compare the long-term…

…in DLB and similarly aged controls. Methods: Thirty-one subjects (15 DLB and 16 controls) underwent I-123-5IA-85380 and perfusion (Tc-99m-exametazime) SPECT scanning. Patient scans were compared to scans of control subjects…

…day, and to evaluate whether normalization to whole brain, compared to normalization to cerebellum, could alter the clinical interpretation of results. Images were analyzed using the simplified reference tissue model…

…measured by autoradiography with [I-125]-(R,R)-I-QNB and [I-125]-(R,S)-I-QNB and compared to M1 ([H-3]pirenzepine) and M2 and M4 ([H-3]AF-DX 384) receptor binding. Binding was calculated in tissue containing striatum, globus pallidus (GPe),…

OBJECTIVE: Cerebral atrophy and white matter lesions (WMLs) are common in older people with common risk factors, but it is unclear if they are related. We investigated whether and to…

Background and Purpose – The commonly quoted early risks of stroke after a first transient ischemic attack (TIA) – 1% to 2% at 7 days and 2% to 4% at…

…anticoagulant therapy (compared with placebo or open control) following presumed non-cardioembolic ischaemic stroke or transient ischaemic attack. SEARCH STRATEGY: We searched the Cochrane Stroke Group trials register. We contacted companies…

Between 3.6 and 6% of the population harbour an unruptured intracranial aneurysm. Risk of rupture is related to aneurysm site and size and whether or not the patient has already…

…of the frequency of small PICHs. Objective To determine whether the rate and timing of CT in community-based stroke incidence studies was adequate to determine accurately the proportion of strokes…

Background Intravenous alteplase is approved for use within 3 h of ischaemic stroke onset, although a meta-analysis of randomised controlled trials suggests treatment benefit up to 4.5 h. We compared…

BACKGROUND: Cytotoxic chemotherapy remains the main systemic therapy for gastro-oesophageal adenocarcinoma, but resistance to chemotherapy is common, resulting in ineffective and often toxic treatment for patients. Predictive biomarkers for chemotherapy…