…mean transit times. Results. The authors found a significant correlation between middle cerebral artery (MCA) mean flow velocity and transit time in the symptomatic (Spearman rank correlation coefficient [rho]=-0.65, P…

A fast and efficient nickel-catalysed iodination reaction of aryl and heteroaryl bromides has been developed. The transformation was found to be general for a wide range of substrates and was…

…15 degree meridians and 10 degree isoptres. Results. Nineteen patients were included in this study. There was a strong statistically significant linear correlation between H (chiasm) and bitemporal (Pearson’s coefficient…

Rapid and efficient radioiodination of aryl and heteroaryl bromides has been achieved using a nickel(0)-mediated halogen-exchange reaction. This transformation gives direct access to [(123)I]- and [(125)I]-imaging agents for single photon…

…hypothesized that late DWI hyperintensity reflected different infarct evolution compared with areas that were isointense by 1 month. Methods – We recruited patients prospectively with ischemic stroke, performed DWI and…

…developed countries particularly hard as their populations age and adopt lifestyles of the more developed countries. Efficient, effective, and rapid diagnosis of stroke and transient ischaemic attack is crucial. The…

A highly efficient and stereoselective synthesis of unnatural cyclic sila-substituted P-amino acids has been developed from simple starting materials. The key step is nucleophilic ring opening of an intermediate aziridine…

The steroid 17-PA is a GABA(A) receptor antagonist which is finding use as a tool in evaluating agonistic/antagonistic activity at GABA(A) receptors. Compounds with improved efficacy over 17-PA would be…

gamma,delta-Unsaturated aldehydes having a fully substituted centre in either the alpha- or beta-positions, have been prepared from substituted gamma-butyrolactones and undergo efficient 4-exo-trig cyclisation on treatment with samarium(II) iodide to…

…a marker of normal neurons) and lactate (a marker of ischemia) to compare with diffusion and perfusion values in the diffusion lesion in acute ischemic stroke. Methods-We recruited patients with…

An efficient two-step, one-pot, biotransformation involving the fluorinase enzyme is described for the synthesis of 5-deoxy-5[F-18]fluororibose, a novel [F-18]-fluorinated sugar suitable for positron emission tomography (PET) applications.

…Computed Tomography (CT) is increasingly used to assess the extent of emphysema and airways disease in patients with COPD, we investigated whether simple attenuation measurement of the thoracic spine on…