…the radiosynthesis of three compounds to be evaluated as novel radiotracers for the histamine H3 receptor. The radiosyntheses of the three target compounds, (123)I-WYE230949, (123)I-WYE126734 and (123)I-WYE127044 were evaluated using…

A significant and largely unsolved problem of computational fluid dynamics (CFD) simulation of flow in anatomically relevant geometries is that very few calculated pathlines pass through regions of complex flow….

…is tested using simulated data and compared with an adaptive thresholding technique using clinical PET data. The results show that the method produces reconstructed images with similar accuracy and noise…

…intelligence quotient (IQ) scores from the same cognitive test available at both 11 and 70 years of age as well as high-resolution brain magnetic resonance imaging data obtained at approximately…

…at 11, recruited 1997-98 to a follow-up study. MEASUREMENTS: participants underwent brain MRI in 1999-2000, to obtain measurements of brain WMH using Scheltens’ scale and a test of fluid intelligence…

…in CBF, CBV, MTT, and < D > for the 3 tissue types was calculated for each patient, a mean value obtained for the population, and the statistical significance determined…

…a prospective observational study. Nicotine dependence was determined by the Fagerstrom test for nicotine dependence (FTND). Volumetric CT acquisitions measuring the percent of emphysema on inspiratory CT (% of lung…

OBJECTIVE: We aimed to investigate three reports of a possible role of early parental death in late onset dementia. We tested a multivariate model of risk factors for late onset…

…years. At wave 1, they underwent assessments of depressive symptoms and the personality traits of neuroticism and extraversion. Brain diffusion magnetic resonance imaging (MRI) data were obtained at the second…

Purpose: To test the reliability of two computational methods for segmenting cerebral iron deposits (IDs) in the aging brain, given that its measurement in magnetic resonance imaging (MRI) is challenging…

…archiving. Aims NeuroGrid aims to develop and test grid technologies for collecting, analysing and interpreting, and secure archiving of neuroimaging data for large multicentre trials in common neurological and psychiatric…

…exposed to the risks of therapy. Responsibility for non-publication lies with investigators, but pharmaceutical companies, research ethics committees, journals and governments can all encourage the timely publication of trial data….