Simon R. Cox – SINAPSE

simon.cox@ed.ac.uk

Organisation:

University of Edinburgh

Department:

Lothian Birth Cohorts, Department of Psychology

Homepage:

http://www.ppls.ed.ac.uk/people/simon-cox

Keywords:

Ageing, Alzheimer's, Cerebral atrophy, Cognitive Control, DTI-tractography, Dementia, Diffusion imaging, Episodic memory, Executive Function, Image analysis, Image processing, Structural imaging

Key Publications:

Full list of publications at: https://scholar.google.co.uk/citations?user=bYhRjYwAAAAJ&hl=en

Cox SR (forthcoming 2024). Neurocognitive ageing. Ann Rev Dev Psychol

Moodie JE, Harris SE, Harris MA, Buchanan CR, Davies G, Taylor A, Redmond P, Liewald D, Valdés Hernández MC, Shenkin S, Russ TC, Munoz Maniega S, Luciano M, Corley J, Stolicyn A, Shen X, Steel D, Waiter G, Sandu-Giuranuic A, Bastin ME, Wardlaw JM, McIntosh A, Whalley H, Tucker-Drob EM, Deary IJ, Cox SR (2024). General and specific patterns of cortical gene expression as spatial correlates of complex cognitive functioning. Human Brain Mapping 45(4), e2664.

Conole ELS, Vaher K, Blesa M, Sullivan G, Stevenson AJ, Quigley AJ, Hall J, Thrippleton M, Murphy L, Bastin ME, Miron VE, Whalley HC, Marioni RE, Boardman JP, Cox SR (2023). Immuno-epigenetic signature derived from saliva associates with the encephalopathy of prematurity and perinatal inflammatory disorders. Brain, Behavior and Immunity 110:322-338.

Corley J, Conte F, Harris SE, Taylor AM, Redmond P, Russ TC, Deary IJ, Cox SR (2023). Predictors of longitudinal cognitive ageing from age 70 to 82 including APOE e4 status, early-life and lifestyle factors. Molecular Psychiatry 28:1256-1271

Jaggi A, Conole ELS, McCracken C, Gkontra P, Raisi-Estabragh, Peterson SR, Cox SR*, Lekadir K* (in press). A structural heart-brain axis mediates the association between cardiovascular risk and cognitive function. Imaging Neuroscience

McCartney DL, Hillary RF, Trejo Bano D, Gadd DA, Walker RM, Nangle C, Flaig R, Campbell A, Murray AD, Harris SE, Porteous DJ, Tucker-Drob EM, McIntosh AM, Evans LK, Deary IJ, Cox SR*, Robinson MR*, Marioni RE*. (2022). Blood-based epigenome-wide analyses of cognitive abilities. Genome Biology 23:26.

Cox SR, Harris MA, Ritchie SJ, Buchanan CR, Valdés Hernández MC, Corley J, Taylor AM, Madole JW, Harris SE, Whalley HC, McIntosh AM, Russ TC, Bastin ME, Wardlaw JM, Deary IJ, Tucker-Drob EM. (2021). Three major dimensions of human brain cortical ageing in relation to cognitive decline across the eighth decade of life. Molecular Psychiatry 26:2651-2662.

Cox SR, Ritchie SJ, Fawns-Ritchie C, Tucker-Drob EM, Deary IJ (2019). Structural brain imaging correlates of general intelligence in UK Biobank. Intelligence, 75, 101376.

Cox SR, Lyall DM, Ritchie SJ, Bastin ME, Harris MA, Buchanan CR, Fawns-Ritchie C, Barbu MC, de Nooij L, Reus LM, Alloza C, Shen X, Neilson E, Alderson HL, Hunter S, Liewald DC, Whalley HC, McIntosh AM, Lawrie SM, Pell JP, Tucker-Drob EM, Wardlaw JM, Gale CR, Deary IJ. (2019). Associations between vascular risk factors and brain MRI indices in UK Biobank. European Heart Journal doi: 10.1093/eurheartj/ehz100

Cox SR, Bastin ME, Ritchie SJ, Dickie DA, Liewald DC, Muñoz Maniega S, Redmond P, Royle NA, Pattie A, Valdés Hernández MC, Corley J, Aribisala BS, McIntosh AM, Wardlaw JM, Deary IJ. (in press). Brain cortical characteristics of lifetime cognitive ageing. Brain Structure and Function doi:10.1007/s00429-017-1505-0.

Cox SR, Ritchie SJ, Dickie DA, Pattie A, Royle NA, Corley J, Aribisala BS, Harris SE, Valdés Hernández MC, Gow AJ, Muñoz Maniega S, Starr JM, Bastin ME, Wardlaw JM, Deary IJ. (2017). Interaction of APOE e4 and poor glycaemic control predicts white matter hyperintensity growth from 73-76 years. Neurobiology of Aging 54, 54-58.

Cox SR*, Ritchie SJ*, Tucker-Drob EM, Liewald DC, Hagenaars SP, Davies G, Wardlaw JM, Gale CR, Bastin ME Deary IJ. (2016). Ageing and brain white matter structure in 3513 UK Biobank participants. Nature Communications, 7:13629.

Cox SR, Dickie DA, Ritchie SJ, Karama S, Pattie A, Royle NA, Corley J, Aribisala BS, Valdés Hernández MC, Muñoz Maniega S, Starr JM, Bastin ME, Evans AC, Wardlaw JM, Deary IJ. (2016). Associations between education and brain structure at age 73 years, adjusted for age 11 IQ. Neurology, 87, 1820-1826.
Cox SR, MacPherson SE, Ferguson KJ, Royle NA, Muñoz Maniega S, Bastin ME, MacLullich AMJ, Wardlaw JM & Deary IJ. (2016). Does white matter or hippocampal volume mediate associations between cortisol and cognitive ageing? Psychoneuroendocrinology 62, 129-37.

Cox SR, Bastin ME, Ferguson KJ, Allerhand M, Royle NA, Munoz Maniega S, Starr JM, MacLullich AMJ, Wardlaw JM, Deary IJ & MacPherson SE (2015). Compensation or inhibitory failure? Testing hypotheses of age-related right frontal lobe involvement in verbal memory ability using structural and diffusion MRI. Cortex 63,4-15

Cox SR, Bastin ME, Ferguson KJ, Munoz Maniega S, MacPherson SE, Deary IJ, Wardlaw JM & MacLullich AMJ (2015). Brain white matter integrity and cortisol in older men: the Lothian Birth Cohort 1936. Neurobiology of Aging 36,257-264.
Cox SR, Ferguson KJ, Royle NA, Shenkin SD, MacPherson SE, MacLullich AMJ, Deary IJ & Wardlaw JM (2014). A systematic review of manual frontal lobe parcellation techniques in magnetic resonance imaging. Brain Structure and Function, 219(1): 1-22.

Books & Book Chapters:
Della Sala S, MacPherson SE, Cox SR, Girardi A & Iveson M. Handbook of Frontal Lobe Assessment (2015). Oxford University Press, Oxford UK.

MacPherson SE & Cox SR (2017). The frontal ageing hypothesis: evidence from normal ageing and dementia In The Handbook of Gerontology Research Methods: Understanding Successful Ageing, Riby, L (Ed). Routledge Psychology Press, UK.