Organisation:
Cancer Research UK Scotland Institute, Glasgow
Department:
Translational Molecular Imaging
Keywords:
Molecular Imaging, Nuclear Medicine, Oncologic Imaging, PET, Preclinical Imaging, Novel Radiotracers, Translational Imaging
Interests:
Dr Gaurav Malviya leading preclinical PET/MRI Imaging facility at the Cancer Research UK Beatson Institute, Glasgow (UK). He did his PhD (University of Rome, Italy) and Postdoc (University of Groningen, The Netherlands), both in the Nuclear Medicine and Molecular Imaging field. Dr Malviya established radionuclide imaging research and UK’s first preclinical integrated PET/MRI imaging facility in the Beatson Institute. Dr Malviya’s research interests include development and preclinical evaluation of novel PET/SPECT imaging radiotracers in advanced cancer murine models, for translational tumour microenvironment imaging.
Research Themes:
https://www.linkedin.com/in/gaurav-malviya-14792555/
Key Publications:
2023
- Dzien P, Mackintosh A, Malviya G, Johnson E, et al. Positron emission tomography imaging of the sodium iodide symporter senses real-time energy stress in vivo. Cancer Metab . 2023; 11(1):14. (IF = 5.9)
- Farahmand P, Gyuraszova K, Rooney C, Malviya G, et al. Asbestos accelerates disease onset in a genetic model of malignant pleural mesothelioma. Front Toxicol. 2023; 27;5:1200650.
- Müller M, May S, Hall H, Kendall T, McGarry L, Blukacz L, Nucifero S, Jamieson T, Leslie J, Phinichkusolchit N, Athineos D, Dhayade S, Sprangers J, Malviya G, Mrowinska A, et al. Human-correlated genetic HCC models identify combination therapy for precision medicine. Published on Research Square (in review for Nature) DOI: 10.21203/rs.3.rs-1638504/v1
2022
- Koessinger AL, Cloix C, Koessinger D, Heiland DH, Bock FJ, Strathdee K, Kinch K, Martínez-Escardó L, Paul NR, Nixon C, Malviya G, Jackson MR, et al. Increased apoptotic priming of glioblastoma enables therapeutic targeting by BH3-mimetics. Cell Death and Differentiation. 2022; 29: 2089–2104. (IF = 15.8)
- Taralli S, Quartuccio N, Malviya G. Editorial: Case reports in PET Imaging. Front Med 2022; 9:1087583. (IF = 5.09)
- Soloviev D, Dzien P, Mackintosh A, Malviya G, Brown G, Lewis D. High molar activity [18F]Tetrafluoroborate synthesis for Sodium Iodide Symporter imaging by PET. EJNMMI Radioph Chem. 2022; 7(1):32. (IF = 4.6)
2021
- Najumudeen AK, Ceteci F, Fey SK, Hamm G, Steven RT, Hall H, Nikula CJ, Dexter A, Murta T, Race AM, Sumpton D, Vlahov N, Gay DM, Knight JRP, Jackstadt R, Leach JDG, Ridgway RA, Johnson ER, Nixon C, Hedley A, Gilroy K, Clark W, Malla SB, Dunne PD, Rodriguez-Blanco G, Critchlow SE, Mrowinska A, Malviya G, Solovyev D, Brown G, Lewis DY, Mackay GM, Strathdee D, Tardito S, Gottlieb E; CRUK Rosetta Grand Challenge Consortium, Takats Z, Barry ST, Goodwin RJA, Bunch J, Bushell M, Campbell AD, Sansom OJ. The amino acid transporter SLC7A5 is required for efficient growth of KRAS-mutant colorectal cancer. Nat Genet. 2021; 53(1):16-26. (IF = 41.38)
- Pandey S, Malviya G, Dvorakova MC. Role of Peptides in Diagnostics. Int J Mol Sci. 2021; 22(16) 8828. doi: https://www.mdpi.com/1422-0067/22/16/8828 (IF = 6.21)
2020
- Cicone F, Malviya G, Sambuceti G. Editorial: Perspectives in small animal radionuclide imaging. Front Med 2020; 7: 262. (IF = 5.09)
- Malviya G, Patel R, Salji M, Martinez RS, Repiscak P, Mui E, Champion S, Mrowinska A, Johnson E, AlRasheedi M, Pimlott S, Lewis DY, Leung HY. 18F-Fluciclovine PET metabolic imaging reveals prostate cancer tumour heterogeneity associated with disease resistance to androgen deprivation therapy. EJNMMI Res 2020; 10(1):143. (IF = 3.14)
2019
- Patel R, Brzezinska E, Repiscak P, Ahmad I, Mui E, Gao M, Blomme A, Harle V, Tan EH, Malviya G, Mrowinska A, Loveridge C, Rushworth L, Edwards J, Ntala C, Nixon C, Hedley A, Mackay G, Tardito S, Sansom O, Leung H. Canonical WNT/ß-catenin signalling induced WNT5A promotes AR-independent Castration-Resistant Prostate Cancer. Cancer Res. 2020; 80(3): 576-590. (IF = 12.7)
2018
- Zmuda F, Blair A, Liuzzi M, Malviya G, Chalmers AJ, Lewis D, Sutherland A, Pimlott SL. An 18F-labeled poly(ADP-ribose) polymerase positron emission tomography imaging agent. J Med Chem 2018; 61: 4103-4014. (IF = 8.04)
- Gonzalez PS, Baudot AD, O’Prey J, Zunino B, Mackay G, Malviya G, Mrowinska A, Roseweir A, Ennis D, McNeish I, Edwards J, Ryan KM. Impairment of tumour growth and enhancement of chemotherapeutic responses by mannose. Nature. 2018; 563(7733):719-723. (IF = 69.5)
2016
- Vis R, Malviya G, Signore A, Grutters JC, Meek B, van de Garde EMW, Keijsers RGM. 99mTc labelled anti-TNF-α antibody for the imaging of disease activity in patients with pulmonary sarcoidosis. Eur Respir J 2016; 47(4):1198-207. (IF = 33.8)
- Malviya G, Nayak T, Gerdes C, Dierckx RA, Signore A, de Vries EF. Isolation and 111In-Oxine Labeling of Murine NK Cells for Assessment of Cell Trafficking in Orthotopic Lung Tumor Model. Mol Pharm 2016; 13(4):1329-38. (IF = 4.94).
2015
- Blair A, Zmuda F, Malviya G, Tavares AAS, Tamagnan GD, Chalmers AJ, Dewar D, Pimlott SL, Sutherland A. A novel 18F-labelled high affinity agent for PET imaging of the translocator protein. Chem Sci, 2015; 6: 4772–4777. (IF = 9.97)
- Galli F, Rapisarda AS, Stabile H, Malviya G, Manni I, Bonanno E, Piaggio G, Gismondi A, Santoni A, Signore A. In Vivo Imaging of Natural Killer Cell Trafficking in Tumors. J Nucl Med 2015; 56(10):1575-80. (IF = 10.06)
- Zmuda F, Malviya G, Blair A, Boyd M, Chalmers AJ, Sutherland A, Pimlott SL. Synthesis and evaluation of a radioiodinated tracer with specificity for poly(ADP-ribose) polymerase-1 (PARP-1) in vivo. J Med Chem 2015; 58(21):8683-93 (IF = 8.04)
- Galli F, Lanzolla T, Pietrangeli V, Malviya G, Ricci A, Bruno P, Ragni P, Scopinaro F, Mariotta S, Signore A. In vivo evaluation of TNF-alpha in the lungs of patients affected by sarcoidosis. BioMed Research International 2015; 2015: 401341. (IF = 2.88)
2014
- Malviya G, Galli F, Sonni I, Signore A. Imaging T lymphocytes in inflammatory diseases: a nuclear medicine approach. Q J Nucl Med Mol Imaging 2014; 58(3):237-57. (IF = 2.87)
- Malviya G, Signore A. Infection and inflammation imaging. Nuclear Medicine and Biology 2014; 41(6): 488. (IF = 2.52)
2013
- Malviya G, Salemi S, Laganà B, Diamanti AP, D’Amelio R, Signore A. Biological therapies for rheumatoid arthritis: progress to date. BioDrugs 2013; 27(4):329-45. (IF = 5.81)
- Malviya G, Nayak TK. PET Imaging to Monitor Cancer Therapy. Curr Pharm Biotechnol 2013; 14 (7): 669-682. (IF = 2.69)
2012
- Malviya G, Anzola KL, Podestà E, Laganà B, Del Mastro C, Dierckx RA, Scopinaro F, Signore A. 99mTc-labeled rituximab for imaging B-lymphocyte infiltration in inflammatory autoimmune disease patients. Mol Imaging Biol 2012; 14 (5): 637-646. (IF = 3.85)
- Conti F*, Malviya G*, Ceccarelli F, Priori R, Iagnocco A, Valesini G, Signore A. Role of scintigraphy with 99mTc-infliximab in predicting the response of intra-articular infliximab treatment in patients with refractory monoarthritis. Eur J Nucl Med Mol Imaging 2012; 39(8):1339-47. (IF = 9.24) * Both authors contributed equally for the first authorship.
- Signore A, Glaudemans A, Malviya G, Lazzeri E, Prandini N, Viglietti AL, Devicienti A, de Vries EFJ, Dierckx RA. Development and testing of a new disposable sterile device for labelling white blood cells. Q J Nucl Med Mol Imaging 2012; 56(4):400-408. (IF = 2.87)
2011
- Malviya G, de Vries EFJ, Dierckx RA, Signore A. Synthesis and evaluation of 99mTc-labelled monoclonal antibody 1D09C3 for molecular imaging of major histocompatibility complex class II protein Mol Imaging Biol 2011; 13 (5): 930-939. (IF = 3.85)
2010
- Malviya G, Galli F, Sonni I, Pacilio M, Signore A. Targeting T and B lymphocytes with radiolabelled antibodies for diagnostic and therapeutic applications. Q J Nucl Med Mol Imaging 2010; 54(6): 654-676. (IF = 2.87)
- Malviya G, Conti F, Chianelli M, Scopinaro F, Dierckx RA, Signore A. Molecular imaging of rheumatoid arthritis by radiolabelled monoclonal antibodies: new imaging strategies to guide molecular therapies. Eur J Nucl Med Mol Imaging 2010; 37(2): 386-398. (IF = 9.24)
- Signore A, Prasad V, Malviya G. Monoclonal antibodies for diagnosis and therapy decision making in inflammation/infection- Foreword. Q J Nucl Med Mol Imaging 2010; 54(6): 671-673. (IF = 2.87)
- Signore A, Mather SJ, Piaggio G, Malviya G, Dierckx RA. Molecular imaging of inflammation/infection: nuclear medicine and optical imaging agents and methods. Chem Rev 2010; 110(5): 3112- 3145. (IF = 60.62)
2009
- Malviya G, D’Alessandria C, Bonanno E, Vexler V, Massari R, Trotta C, Scopinaro F, Dierckx RA, Signore A. Radiolabeled Humanized Anti-CD3 monoclonal antibody visilizumab for imaging human T-lymphocytes. J Nucl Med 2009; 50(10): 1683-1691. (IF = 10.06)
2008
- Malviya G, Lagàna B, Signore A, Dierckx RA. Radiolabeled peptides and monoclonal antibodies for therapy decision making in inflammatory diseases. Curr Pharm Design 2008; 14(24): 2401-2414. (IF = 4.7)
- Chianelli M, Boerman OC, Malviya G, Galli F, Oyen WJG, Signore A. Receptor binding ligands to image infection. Curr Pharm Design 2008; 14 (31): 3316-3325. (IF = 4.7)
2007
- D’Alessandria C*, Malviya G*, Viscido A, Aratari A, Maccioni F, Amato A, Scopinaro F, Caprilli R, Signore A. Use of a 99m-Technetium labelled anti-TNFa monoclonal antibody in Crohn’s Disease: in vitro and in vivo studies. Q J Nucl Med Mol Imaging 2007; 51:1-9. (IF = 2.87) * Both authors contributed equally for the first authorship.
BOOK CHAPTERS
2023
- Malviya G, Singh PK. Molecular imaging: from the cellular players to bedside. Molecular Diagnostics in Medicine and its applications in Cancer management; Elsevier Ltd., The Netherlands. (In press)
2022
- Malviya G, Siow B. Hybrid PET/MR systems. Encyclopaedia of Nuclear Medicine and Molecular Imaging; Elsevier Ltd., The Netherlands. (ISBN: 9780128229606)
2014
- Signore A, de Vries EFJ, Galli F, Malviya G. Applications of molecular small-animal imaging in inflammation and infection. Molecular Imaging of Small Animals: Instrumentation and Applications; Springer, New York, USA. (ISBN: 9781493908943)
2013
- Chianelli M, Malviya G, Glaudemans A, Signore A. Nuclear medicine imaging of inflammatory diseases. Diagnostic imaging of infections and inflammatory diseases: a multidisciplinary approach; John Wiley & Sons Inc Publication, UK. (ISBN:9781118484418)
2009
- Chianelli M, Fernandaz A, Malviya G (Editors). Radiolabelled Blood Elements. Newsletter of the International Society of Radiolabelled Blood Elements, Volume 15, No.1, 2009.
Software Expertise:
PMOD (https://www.pmod.com/web/)