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I am a clinical cardiothoracic radiologist with experience in lung, cardiovascular and oncologic imaging. I am interested in multidisciplinary research approaches with the application of novel imaging techniques and advanced quantitative software tools to provide better analysis of disease states and wish to develop imaging as a biomarker. In addition to the relatively traditional single organ system approach, I am interested in the interactions of these systems within the larger groups of diseases, including COPD, asthma, atherosclerosis and cancer. Towards this end, I intend to develop programs that will appeal to multiple specialities that may not currently be working together within a single group of researchers. Apart from these ideas and interests, I am trained in Clinical Epidemiology and am interested in developing Evidence Based Radiology into clinical practice and build this within the registrar training scheme. It is my firm belief that this will aid in developing an academic career pathway within Radiology. My current role is that of director of the clinical research imaging centre, which houses 3T MRI, 128 PET-CT and 320 detector row CT. This is supported by a GE cyclotron with a fully functional MHRA inspected GMP radiochemistry facility as well as a research laboratory, allowing clinical/research production as well as development of novel radiotracers. An integrated advanced image analysis laboratory completes the centre.
Research Themes:
Respiratory Medicine Imaging Cardiovascular Imaging (both systemic and pulmonary circulation) Molecular and Oncologic Imaging
Key Publications:
Shroff R, Kirschner A, Maifeld M, van Beek EJR, Jagasia D, Dokras A. Young obese women with PCOS have evidence of early coronary atherosclerosis. J Clin Endocrinol Metabol 2007;92:4600-4614.
Van Beek EJR, Dahmen AM, Stavngaard T, et al. Comparison of hyperpolarised 3-He MRI and HRCT in normal volunteers, patients with COPD and patients with alpha-1-antitrypsin deficiency – PHIL trial. Eur Resp J 2009;34:1311-1321.
Lederer DJ, Enright PL, Kawut SM, et al. Cigarette smoking is associated with subclinical parenchymal lung disease: The MESA-Lung Study. Am J Respir Crit Care Med 2009;180:407-414.
Van Beek EJR, Malone DE. Evidence Based Radiology: why and how should we teach it? Radiology 2007;243:633-640.
Washko GR, Hunninghake GM, Fernandez IE, et al. for COPDGene Investigators. Lung volumes and emphysema in smokers with interstitial lung abnormalities. N Engl J Med 2011;364:897-906.
Condliffe R, Radon M, Hurdman J, et al. CT pulmonary angiography combined with echocardiography in suspected systemic sclerosis-associated pulmonary arterial hypertension. Rheumatology 2011;50:1480-1486.
Han MK, Kazerooni EA, Lynch DA, et al. for COPDGene Investigators. Chronic obstructive pulmonary disease exaerbations in the COPDGene study: associated radiologic phenotypes. Radiology 2011;261:274-282.
Dweck MR, Jones C,, Joshi N, et al. Role of active valvular calcification and inflammation in patients with aortic stenosis. Circulation 2012;125:76-86.
Maclay JD, McAllister DA, Rabinovich R, et al. Systemic elastin degradation in chronic obstructive pulmonary disease. Thorax 2012;67:606-612.
Wells JM, Washko GR, Han MK et al. for COPDGene Investigators. Pulmonary arterial enlargement and acute exacerbations of COPD. N Engl J Med 2012;367:913-921.
Romme EAPM, Murchison JT, Phang KF, et al. Bone attenuation on routine chest CT correlates with bone mineral density on DXA in patients with COPD. J Bone Mineral Res 2012;27:2338-2343.
Dweck MR, C how MWL, Joshi N, et al. Coronary arterial 18F-NaF uptake – a novel marker of cardiovascular risk. J Am Coll Cardiol 2012;59:1539-1548.
Collaborators:
Harm Tiddens (Erasmus University, Rotterdam, the Netherlands) International
Graham Barr (Columbia University, New York, NY) International
Kevin Flaherty (University of Michigan, Ann Arbor, MI) International
Matthijs Oudkerk (State University Groningen, Groningen, the Netherlands) International
Hans-Ulrich Kauczor (University of Heidelberg, Heidelberg, Germany) International
Eric Hoffman (University of Iowa, Iowa City, IA) International
Jim Wild (University of Sheffield) United Kingdom
David Kiely (University of Sheffield) United Kingdom
David Lynch (National Jewish Hospital, Denver, CO) International
James Crapo (National Jewish Hospital, Denver, CO) International
Bill MacNee (University of Edinburgh) Scotland
David Newby (University of Edinburgh) Scotland
John Murchison (Lothian University Health Trust) Scotland
Yoshi Ohno (Kobe University, Kobe, Japan) International
Saeed Mirsadraee (University of Edinburgh) Scotland
The list is much longer and I apologise if I forgot to mention anyone !