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Interests:
I enjoy working at the interface of multiple disciplines, such as physics, mathematics, neurobiology, and cognitive neuroscience, as this provides an excellent platform to translate cutting-edge imaging methods research into novel clinical applications. I am particularly interested in the development and optimisation of quantitative neuroimaging methods and their applications to study normal cognitive function, impaired consciousness, dementia, normal ageing, stroke and depression. My current research activities include: (i) functional MRI and PET in disorders of consciousness (e.g. coma, vegetative state, minimally conscious state); (ii) functional and structural MRI in stroke; (iii) functional connectivity MRI in depression; (iv) microvascular MRI and cerebrovascular reactivity mapping in normal ageing and dementia.
Research Themes:
magnetic resonance imaging (MRI); neuroimaging; functional MRI (fMRI); functional connectivity MRI; microvascular MRI; positron emission tomography (PET); impaired consciousness; coma; vegetative state; minimally conscious state; anaesthesia; ischaemic stroke; transient ischaemic attack (TIA); major depressive disorder (MDD).
Key Publications:
J. S. Perrin, S. Merz, D. M. Bennett, J. Currie, J. D. Steele, I. C. Reid, C. Schwarzbauer. Electroconvulsive therapy reduces frontal cortical connectivity in severe depressive disorder. PNAS 109: 5464-5468 (2012).
C. Schwarzbauer, R. Deichmann. Vascular component analysis of hyperoxic and hypercapnic BOLD contrast. Neuroimage 59: 2401–2412 (2012).
Y. Shen, T. Ahearn, M. Clemence, C. Schwarzbauer. Magnetic Resonance Imaging of the Mean Venous Vessel Size in the Human Brain Using Transient Hyperoxia. Neuroimage 55: 1063–1067 (2011).
C. Schwarzbauer, M. H. Davis, J. Rodd, I. Johnsrude. Interleaved silent steady state (ISSS) imaging: Applications to event-related auditory fMRI. Neuroimage 29: 774-82 (2006).
R. Salvador, J. Suckling, C. Schwarzbauer, E. T. Bullmore. Undirected graphs of frequency-dependent functional connectivity in whole brain networks. Philos. Trans. R. Soc. Lond. B. Biol. Sci. 360: 937-946 (2005).
R. Deichmann, C. Schwarzbauer, R. Turner. Optimisation of the 3D MDEFT sequence for anatomical brain imaging: technical implications at 1.5 and 3 T. Neuroimage 21: 757-767 (2004).
C. Schwarzbauer, S. P. Morrissey, A. Haase. Quantitative magnetic resonance imaging of perfusion using magnetic labeling of water proton spins within the detection slice. Magn. Reson. Med. 35: 540 (1996).
Collaborators:
Dr Gaby Lohmann, Leipzig, Germany
Dr Toralf Mildner, Leipzig, Germany
Dr Matthew Brett, Berkeley, USA
Prof Ralf Deichmann, Frankfurt, Germany
Dr David Porter, Siemens Healthcare, Germany
Dr Bjoern Schelter, Freiburg, Germany
Prof Boris Kotchoubey, Tuebingen, Germany
Prof Douglas Steele, Dundee, UK
Prof Joanna Wardlaw, Edinburgh, UK
Prof Keith Muir, Glasgow, UK
Prof Ian Reid, Aberdeen, UK
Dr Jennifer Perrin, Aberdeen, UK
Dr Mary Joan MacLeod, Aberdeen, UK
Dr Matthew Clemence, Philips Medical, UK
Prof Amanda Lee, Aberdeen, UK
Dr Lorna Aucott, Aberdeen, UK
Dr Helen Gooday, NHS Grampian, Aberdeen, UK
Dr Steve Stott, Aberdeen, UK
Prof Nigel Webster, Aberdeen, UK
Dr Marco Thiel, Aberdeen, UK